Comprehensive, web based and easy to access database, PK/DB manages 1389 compounds incorporating structurally diverse drug-like and lead-like molecules which represent 4141 pharmacokinetic measurements, including five validated models for in silico ADME prediction. The PK/DB suite is designed to be utilized by all researchers in the drug discovery field, and will be continuously updated and upgraded as new information becomes available.
PK/DB was created under the direction of Prof. Dr. Adriano D. Andricopulo by Dr. Tiago L. Moda and collaborators at the Laboratory of Computational and Medicinal Chemistry. For more click here.
|Human Intestinal Absorption (%HIA)||687|
|Human Oral Bioavailability (%F)||660|
|Plasma Protein Binding (%PPB)||726|
|Blood Brain Barrier (logBB)||200|
|Volume of Distribution (Vd (L/kg))||738|
|Renal Clearance (%Cl)||360|
|Half Life (T1/2(h))||770|
|Known CYP for Metabolism||295|
To cite PK/DB, please reference: Moda, T. L.; Torres, L. G.; Carrara, A. E.; Andricopulo, A. D. Bioinformatics 2008, 24, 2270